منابع مشابه
DNA replication: enzymology and mechanisms.
Research into the enzymology of DNA replication has seen a multitude of highly significant advances during the past year, in both prokaryotic and eukaryotic systems. The scope of this article is limited to chromosomal replicases and origins of initiation. The multiprotein chromosomal replicases of prokaryotes and eukaryotes appear to be strikingly similar in structure and function, although fut...
متن کاملThe Enzymology of DNA Replication
4. SEALING OF DNA FRAGMENTS 219 4.1. E. coli DNA ligase 4.2. Bacteriophage T 4 gene 30 protein 4.3. Mammalian DNA ligases I and II C O N F O R M A T I O N A L CHANGES OF DNA DURING REPLICATION 220 5.1. E. coli HDP 5.2. Bacteriophage-coded HDPs — T 4 gene 32 protein —T7 HDP —fd gene V protein 5.3. Eukaryotic HDPs 5.4. Bacterial DNA topoisomerases —Swivelases —DNA gyrase 5.5. Bacteriophage-coded ...
متن کاملWIMP dark matter detectors above 100 K
Of key motivation in the development of detector strategies in the search for Weakly Interacting Massive Particles (WIMPs) is the need to maximize the information obtainable from the expected elastic recoil events so that these can be distinguished from background interactions and systematic errors can be controlled. Low temperature techniques may provide one route. However, most of the detecto...
متن کاملThe DNA enzymology of protein machines.
When I was asked to prepare this introduction, I very nearly declined. Being not nearly as wise as Alan Campbell, I knew that I could not attempt to match his scholarly introduction to the 1980 Cold Spring Harbor Symposium, the last Symposium to deal with these issues. Also, unlike him, my own contributions to the area of genetic recombination have been quite modest. I completely missed out on ...
متن کاملProtein thermostability above 100°C: A key role for ionic interactions
The discovery of hyperthermophilic microorganisms and the analysis of hyperthermostable enzymes has established the fact that multisubunit enzymes can survive for prolonged periods at temperatures above 100°C. We have carried out homology-based modeling and direct structure comparison on the hexameric glutamate dehydrogenases from the hyperthermophiles Pyrococcus furiosus and Thermococcus litor...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.23.13593